The movie When In Rome is about Beth (Kristen Bell), a girl, that is unlucky in love. At her sister’s wedding in Italy, Beth decides to change that. After the wedding, Beth visits the legendary fountain of love, and decides to take some love with her. She steals several coins from the fountain, only later learning that by doing so the owners of the coins would magically fall in love with her.

Back in the States, Beth is heavily pursued by the owners of the coins, all of whom Beth rejects, except for one, Nick (Josh Duhamel). But does Nick really love Beth or is it all an illusion of the coin?